Genome-wide association studies look for DNA changes linked to diseases.
These studies focus mainly on the DNA sequence, the order of its letters.
The new research indicates many inherited differences lie outside that sequence.
Missing these differences may limit the ability to predict health risks.
Broader approaches could give a fuller picture of genetic influence.
This hidden variation could explain why some diseases are still hard to predict.
The authors recommend expanding research beyond the usual DNA sequence to capture the missing pieces.
Doing so could improve how doctors understand and treat genetic conditions.
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