DZIP3 acts as a dual‑action sensor that detects viral ribonucleic acid.
Upon detection, DZIP3 changes shape and relocates to mitochondria.
It tags and activates immune proteins, leading to production of Type‑I interferons.
The pathway provides protection against viruses such as COVID‑19, Chikungunya and Japanese Encephalitis.
Researchers are developing small‑molecule drugs to boost DZIP3 for wide‑range antiviral therapy.
DZIP3 changes shape when it binds viral ribonucleic acid and moves to the mitochondria, the cell’s energy factories.
In the mitochondria it activates key immune proteins that produce Type‑I interferons, powerful molecules that block virus replication.
The finding opens possibilities for drugs that enhance DZIP3 activity to provide broad‑spectrum antiviral protection.
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